The mag drive can be run in line or submersible. Little Giant pumps are all in line (they make some freshwater pumps that are submersible). The biggest difference is heat transfer. LGs have a fan to disperse the heat, while the Mags all use the water to cool the pump. Since I believe you can never have too strong a pump (you can always tee it off to various other devices, or just reduce the flow), I would go with the LG. In a 55, the heat transfer from a larger submersible pump will have more of an impact on your tank temperature versus if you had a 200 (although, you'd probably go with a bigger pump). In line, IMO is better, but I use both in line and submersible (I am currently using a mag drive 1200 (?), a LG 4MD something or other, and a Dolphin Ampmaster 3000. There's also a difference in noise, as the fan will create a humming noise that won't be present in your mag drive pump.