Have two Hippo Tangs in 155 gal fish only tank. The fish are about five years old and are family favorites. About once a year or so (since I've had them) they break out with what looks like pimples that push out from inside of their bodies and have white tips on top of the pimples. I've had good results with treatment of penicillin and melafix in the past. About two months ago I installed a 150 gal refuguim in basement and got rid of my wet/dry. Things went well for month then the pimples appeared on both fish and got progressively worse. I moved both Hippos to 29 gal hospital tank with divider to separate them. I started with one cycle of penicillin - no luck. Changed water and waited two days then one five day cycle of Maracyn with copper safe- seemed to be working but they broke out out again. I did one more five day cycle of Maracyn and today would have been the fifth day but they are completely broken out again. Today I changed 80% of hospital tank and dosed with Metranydozole as per "Jim" at Marine Depot. Don't know what else to do. Any suggestions for treatment or any clue as to what the problem is with fish? My water parameters / quality / temperature are all perfect.