There can be some issue with dead water space if the water does not circulate, but that is just a waste of valueable water space that could be used for something else. Otherwise, get a smaller tank.
If the water is made to recirculate, it can be difficult if fine sand is used. If coarse medium is used (crusted shell/coral), it trapes junk and need to be vacc'ed like all freshwater tank. It can be a real hassle if you need to move the rock work around.
All in all, there are other alteratives that achieve the same function, such as wet/dry and bio-wheel, without the disadvantage. Consider that these "better" alternative is not really useful in most reef (cf. fish only) setup, you can be sure that UGF is not really a good idea for reef tank.