Not sure what you mean by this in relation to algae scrubbers? I don't run a scrubber, but I do rely primarily on Chaetomorpha for filtration--i.e. no skimmer. I do run carbon 24/7 to deal with yellowing compounds etc. and will run GFO on occasion if needed.
I have one on my 80 and will be setting up a new one this week for for my new system. I've noticed huge improvement in water quality and clarity. I only run my skimmer 12 hours a day and have pushed wc's to twice a month at 15%. huge thread on rc about them.